fdb - Frequentist Dynamic Borrowing for Hybrid-Control Survival Trials
Implements a class of likelihood-informed frequentist
dynamic borrowing methods for hybrid-control survival trials
based on penalized Cox partial likelihood estimation.
Implements four likelihood-informed penalty structures
(precision-weighted L1, smoothed integrated-gate,
information-adaptive minimax concave penalty (MCP), and
likelihood-ratio-weighted L1), together with the adaptive lasso
borrowing approach of Li et al. (2023,
<doi:10.1002/bimj.202100406>). Provides conditional model-based
standard errors and local plug-in sandwich variance
approximations, with smoothed penalties. Tools for design-stage
lambda calibration via simulation, including a two-stage
coarse-fine grid search, drift-level early stopping, and
per-method tuning under both inference types, are also
provided. A simulation harness for evaluating type I error and
statistical power across population drift scenarios is
included.